Inflammation and Cellular Redox States

It is well understood that highly toxic oxidants called “reactive oxygen species (ROS)” are produced by phagocytic cells as part of the innate immune response to infection.

In recent years, ROS and consequently the oxidation-reduction (redox) state of immune cells have been recognized as key players in the inflammatory response to both infectious and non-infectious cues. Pediatric diseases with inflammatory complications and signs of redox imbalance include chronic granulomatous disease (CGD), cystic fibrosis, and the autoinflammatory diseases SAPHO, PFAPA, TRAPS and FMF.

Whether oxidants suppress or promote inflammatory signaling and to what extent they influence the biology of an inflammatory response remains controversial. This project aims to understand redox-sensitive signaling molecules in the context of inflammatory disease and their potential as novel therapeutic targets.

Neutrophil phagolysosome formation and production of highly toxic reactive oxygen species (ROS) (From: Bylund et al (2010) Free Radic. Biol. Med. 49: 1834-1845)

Selected Publications

  • Galectin-3 modulates microglia inflammation in vitro but not neonatal brain injury in vivo under inflammatory conditions

    Sävman K, Wang W, Rafati AH, Svedin P, Nair S, Golubinskaya V, Brown KL, Karlsson A, and Mallard C.

    (2021) Developmental Neuroscience In Press. PubMed

  • Elevated mitochondrial reactive oxygen species and cellular redox imbalance in human NADPH-oxidase-deficient phagocytes

    Sundqvist M, Christenson K, Björnsdottir H, Osla V, Karlsson A, Dahlgren C, Speert DP, Anders F, Bylund J* and Brown KL*. (* authors contributed equally).

    (2017) Frontiers Immunology 8: 1828. PubMed

  • Innate defence regulatory peptide protects against neonatal brain injury

    Boulouri H, Sävman K, Wang W, Thomas A, Maurer N, Dullaghan E, Fjell CD, Hagberg H, Hancock REW, Mallard C*, Brown KL*. (* authors contributed equally).

    (2014) Annals of Neurology 75: 395. PubMed

  • Intracellular Generation of Superoxide by the Phagocyte NADPH-Oxidase; How, Where, and What for?

    Bylund J, Brown KL, Movitz C, Dahlgren C and Karlsson A.

    (2010) Free Radic. Biol. Med. 49: 1834-1845. PubMed