Research
Publications
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Behcet’s Syndrome - Recent advances to aid diagnosis
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Anti-LAMP-2 antibody seropositivity in children with primary systemic vasculitis affecting medium and large blood vessels
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Hyaluronan promotes intracellular ROS production and apoptosis in TNFα-stimulated neutrophils
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Elevated adenosine deaminase 2 (ADA2) enzyme activity at the onset of chronic Graft-versus-Host Disease in children
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HLA-DBP1 is associated with ANCA-associated vasculitis in children
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Pathogenic variant c.1052T>A (p.Leu351Gln) in adenosine deaminase 2 impairs secretion and elevates Type I IFN responsive gene expression
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Children with systemic autoinflammatory diseases have multiple, mixed ethnicities that reflect regional ethnic diversity
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Latent gamma herpes virus exacerbates arthritis and requires age-associated B cells
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Galectin-3 modulates microglia inflammation in vitro but not neonatal brain injury in vivo under inflammatory conditions
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Different disease endotypes in phenotypically similar vasculitides affecting small-to-medium sized blood vessels
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Autoantibodies against lysosome associated membrane protein-2 (LAMP-2) in pediatric chronic systemic vasculitis
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Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group
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Anti-neutrophil cytoplasmic antibodies (ANCA): Antigen interactions and downstream effects
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Hyaluronan primes the oxidative burst in human neutrophils
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Adenosine Deaminase 2 activity negatively correlates with age during childhood
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Complexity in unclassified auto-inflammatory disease: A case report illustrating the potential for disease arising from the allelic burden of multiple variants
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Comparable type I interferon score determination from PAXgene and Tempus whole blood RNA collection and isolation systems
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Periodic fever Syndromes: beyond the single gene paradigm
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Identification of novel ADA2/CECR1 gene variants and varied clinical phenotype in pediatric vasculitis
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The value of creativity for enhancing translational ecologies, insights, and discoveries
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Methods for type I interferon detection and their relevance for clinical utility and improved understanding of rheumatic diseases. Review
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Monocyte-derived interleukin-1 as the driver of S100A12-induced sterile inflammatory activation of human coronary artery endothelial cells: Implications for the pathogenesis of Kawasaki Disease
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S100A12 and common inflammatory markers improve assessment of disease activity in a PedVas cohort of childhood systemic vasculitis
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Elevated mitochondrial reactive oxygen species and cellular redox imbalance in human NADPH-oxidase-deficient phagocytes
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Measles Lymphadenopathy in a Child With PFAPA Syndrome
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Clinical practice variation and need for pediatric-specific treatment guidelines among rheumatologists caring for children with ANCA-associated vasculitis: an international clinician survey
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The Importance of Considering Monogenic Causes of Autoimmunity: A Somatic Mutation in KRAS Causing Pediatric Rosai-Dorfman Syndrome and Systemic Lupus Erythematosus
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Temporal characterization of microglia/macrophage phenotypes in a mouse model of neonatal hypoxia-ischemic brain injury
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Purified hyaluronan and hyaluronan fragments do not stimulate pro-inflammatory cytokine production in dendritic cells or macrophages
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Pediatric Vasculitis: Advances in Treatment
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The where, when, how and why of hyaluronan binding by immune cells
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Innate defence regulatory peptide protects against neonatal brain injury
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Increased intracellular oxygen radical production in neutrophils during febrileepisodes of PFAPA syndrome
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Antimicrobial, Host Defence Peptides and Proteins (version 3)
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On the road to discovery in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome
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Differential use of chondroitin sulfate to regulate hyaluronan binding by CD44 in inflammatory and interleukin activated macrophages
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Host defence peptide LL-37 selectively reduces pro-inflammatory macrophages responses
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Galectin-3 aggravates joint inflammation and destruction in antigen-induced arthritis
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Intracellular Generation of Superoxide by the Phagocyte NADPH-Oxidase; How, Where, and What for?
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Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome
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Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity
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G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9
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Divergent effects on phagocytosis by macrophage-derived oxygen radicals
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Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome
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Treating Neonatal Brain Injury - Promise and Inherent Research Challenges
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Galectin-3 functions as an opsonin and enhances macrophage clearance of apoptotic neutrophils
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ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease
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The host defence peptide LL-37 selectively permeabilises apoptotic leukocytes
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Antimicrobial Host Defence Peptides of Human Neutrophils - Roles In Innate Immunity
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Is Innate Host Defense the Answer?
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Phagocyte-derived reactive oxygen species as suppressors of inflammatory disease
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Complexities of Targeting Innate Immunity to Treat Infection
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Antimicrobial, Host Defence Peptides and Proteins
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Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NFκB
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IRAK-4 mutation (Q293X): rapid detection, and characterization of defective post-transcriptional TLR/IL1R responses in human myeloid and non-myeloid cells
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Modulation of the Toll-like receptor-mediated inflammatory response by the endogenous human host defence peptide LL-37
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Cationic Host Defence (Antimicrobial) Peptides
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Host defence peptides from invertebrates – emerging antimicrobial strategies
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Bovine and human cathelicidin cationic host defence peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide